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In vitro studies demonstrate that IGF-1 promotes the proliferation of dermal papilla cells and keratinocytes, the key cell types involved in hair production

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The protective effect was associated with activation of the Sirt1/HO-1 signaling pathway, which is mechanistically relevant because SIRT1 influences inflammatory gene expression and stress tolerance, while HO-1 is a key cytoprotective effector induced during oxidative and inflammatory stress [121]