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Intriguingly, the histological changes in hippocampus after treatment with TPPU + DHA showed significant protection of neurons against STZ-induced neuronal damage

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Astrocytic activation is regulated by Bmal1 , shown through activation and increased inflammatory gene expression using an astrocyte specific Bmal1 knockout ( Bmal1 knockouts in astrocyte cultures have reported reduced actin-binding protein cortactin and impaired actin stress fiber formation ( Other immune cell populations that are involved in regulating the progression of ischemic injury are neutrophils, macrophages, and T-cells (Jian et al., 2019)