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Badenhorst and colleagues, in a 2016 study, reported that GHK-Cu increased both collagen and elastin production in human dermal fibroblasts and shifted the expression ratio of tissue inhibitors of metalloproteinases relative to the metalloproteinases themselves, which is the direction associated with building matrix rather than breaking it down

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Acknowledgements This work was supported by the Zhejiang Provincial Natural and Science Foundation of China under Grant (LD22H310004), Zhejiang Provincial Natural and Science Foundation (LQN25C070001), Zhejiang Sci-Tech University Research Start-up Fund (24042191-Y)