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The KEAP1 protein detects oxidative stress by going through a conformational change that prevents association with NRF2, leading to NRF2 accumulation and translocation to the nucleus, which then induces transcription through antioxidant response elements found in a broad set of genes involved in redox homeostasis and correcting oxidative damage
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This enzymatic reaction is represented by the equation: The importance of this reaction cannot be overstated, as glutathione is the most abundant non-protein thiol in cells and serves as the cornerstone of cellular antioxidant defense
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