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Vitamin B 12 deficiency can develop with heavy regular use of nitrous oxide N 2 O, also known as "laughing gas", used for anaesthesia in a clinical setting or as a propellant gas, commonly abused as a recreational drug

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Consequently, researchers have investigated whether supplementing glutathione or supporting its production might benefit individuals with liver conditions, including fatty liver disease, though evidence remains limited and such supplementation is not part of standard UK clinical practice