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In obesity, the spontaneous (197, 198) and stimulated (199) pulsatile patterns of GH secretion governed by the hypothalamus are blunted, and the accumulation of abdominal adiposity, particularly visceral adipose tissue mass, was found to be a stronger negative determinant of GH secretion than other factors including age, sex, or generalized obesity (200–202)

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Mechanism of Action: The Science Behind the Dual Agonism Amycretin is a single peptide engineered from two covalently linked analogs — one derived from GLP-1, one from amylin