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357 The in vitro culture of telomere-binding protein protection of telomeres 1 (Pot1) in HSCs has been demonstrated to maintain self-renewal capacity and regulate the activity of HSCs in elderly individuals, which has significant implications for the ex vivo cultivation of human HSCs

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This is also true for the newborn screening of inborn errors of vitamin B 12 metabolism found in the cblD, cblF, and cblJ (Huemer et al., 2015) disorders