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Pyridoxal kinase (PDXK) is expressed in many tissues, with its highest expression being in the cerebral cortex and basal levels in the adrenal gland, lung, breast, gastrointestinal tract, urinary tract, testis, and adipose tissue [133]

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4.4.4.5 Biomarker integration for disease staging and intervention monitoring The metabolite panel encompassing IS, pCS, PAGln, circulating BCAAs, and homocysteine provides a comprehensive readout of gut-liver-kidney axis dysregulation