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It also enhances fecal particle count, water content, intestinal propulsion rate, and ameliorates colon pathological damage and depression-like behaviors, potentially by modulating the function of interstitial cells of Cajal (ICCs) through targeting microtubule-associated protein tau (MAPT) in colon tissue

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A double-blind study in chronic insomniac patients did not produce a clean confirmation of benefit (PMID 1299794), and other human work has treated the endogenous compound as a marker rather than a confirmed sleep agent