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Prominent in neurons, but not glial cells, GIP synthesis is more distributed in the CNS compared to GLP-1 and was identified in the hippocampal CA1-3, granule cell layer and neurogenic niche of the dentate gyrus, thalamus, cerebral cortex, cerebellum (Purkinje cells) and brainstem

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The GI side effect rates are higher than what is typically seen with semaglutide alone (around 74 percent in OASIS 4), which makes sense given that CagriSema combines two appetite-suppressing mechanisms