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Chronic hypoxia-induced α-syn pathology and cognitive impairment in mice remain irreversible after reoxygenation We have found that chronic hypoxia promoted the abnormal pathology of α-syn through an HIF-2α-dependent pathway, which is an important link in inducing neuronal injury and cognitive impairment in mice

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the specific binding portions of both molecules can be part of a known specific binding pair (e.g., biotin, streptavidin) or can result from peptide generation methods such as those described herein