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doi: 10.1210/jc.2005-1536 81 CorpasEHarmanSMPiñeyroMARobersonRBlackmanMR

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Key Differences for Experimental Design | Dimension | Dihexa | Cerebrolysin | | --- | --- | --- | | Chemical nature | Defined synthetic peptidomimetic | Complex brain-derived peptide mixture | | Mechanistic focus | HGF/c-Met–centered hypotheses | Multimodal neurotrophic / protective | | Analytics | Single-analyte LC-MS/HPLC friendly | Fingerprint / peptide profile methods | | Attribution of effects | Higher (one scaffold) | Distributed across constituents | | Typical rationale | Targeted synaptogenic pathway work | Broad neuroprotection & recovery models | | Formulation complexity | Generally simpler defined solutions | Mixture stability and handling nuances | Practical lab consequences - **Hypothesis testing:** Prefer Dihexa when the question is pathway-specific (c-Met dependence, dose–response at a defined ligand)