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This hypothesis motivated decades of experiments, including techniques like cross-circulation between sleep-deprived and rested animals, aimed at identifying a blood-borne "sleep factor." Only two peptides emerging from this broader research programme were ever purified to homogeneity and fully characterised: DSIP and, separately, a peptide known as sleep-promoting substance identified through related methods

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Or the physician could say, you know what, I'm not making a dime on this