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During translation of preproinsulin from its mRNA, the N-terminal signal peptide is cleaved to yield proinsulin
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Oxidative and reductive processes in biological systems Oxidation of proteins in cells can be (i) part of a normal enzymatic mechanism, (ii) caused by reactive oxygen species (ROS) elicited as a side product through “leakage” of electrons from the electron transport chain during normal metabolism, (iii) a result of ROS generated from toxins or damaging agents, or (iv) evoked following the regulated generation of cellular oxidants for signaling purposes (Fig
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