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doi: 10.3389/fimmu.2025.1519300 Received 29 October 2024 Accepted 23 January 2025 Published 12 February 2025 Volume 16 - 2025 Edited by John Williams, City of Hope, United States Reviewed by Federico Simonetta, Hôpitaux Universitaires de Genève (HUG), Switzerland Nora Heisterkamp, City of Hope, United States Updates Copyright © 2025 Horenstein, Faini, Morandi, Ortolan, Storti, Giuliani, Richardson and Malavasi

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Figure 2 shows that rates of fatigue remained high at 3 months for those who had low, borderline and normal B12 rates at baseline