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This may be important since BPC 157 itself not only increased Vegfr2 expression in vascular endothelial cells but also immediately triggered the internalization of Vegfr2 and subsequent phosphorylation of Vegfr2 , Akt, and Nos3 signaling pathways without other known ligands or shear stress (Hsieh et al., 2017)

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Denver Health, Denver VA Medical Center, Kaiser Permanente Colorado and National Jewish Health)