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It’s thought that cold exposure activates your sympathetic nervous system, lowering levels of the pro-inflammatory cytokines that contribute to chronic inflammation [12]

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Exportin-1 (XPO1) Inhibition Sequesters p53 from MDM2 and MDM4 and is Highly Synergistic with MDM2 Inhibition in Inducing Apoptosis in Wild-type p53 Acute Myeloid Leukemias