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Keywords: Epilepsy, Epileptic encephalopathy, FUT2, Infantile spasms, Vitamin B12, Vitamin-responsive epileptic encephalopathies Background Developmental and epileptic encephalopathy (DEE) is a rare group of disorders presenting in infancy with severe early-onset epilepsy, in which the neurodevelopmental comorbidity may be attributable to both the underlying cause and the adverse effects of uncontrolled epileptic activity [1]