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DSIP (delta sleep-inducing peptide) was first isolated from rabbit cerebral venous blood in 1974 and has accumulated a small but published clinical-trial base — most notably a 1992 Schneider-Helmert study showing improved sleep with DSIP infusion in chronic insomniacs over 7 successive nights and earlier studies showing improved sleep duration in middle-aged chronic insomniacs
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ROS enhance tumor survival via NF-κB/Nrf2 activation, upregulating antioxidant (SOD) and anti-apoptotic (Bcl-2) mediators, directly driving chemoresistance
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