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Plasma biomarkers, such as riboflavin and FMN, have also shown promising outcomes and are responsive to low-dose riboflavin supplementation, while plasma FAD concentrations have only shown mild responses to intervention [17]

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The weakening of the heart muscle may lead to the swelling of the lower legs and feet, lung, liver, and the lining of the intestine (Motohashi et al., 2017)