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in Cell Metabolism note that SIRT1 activation improves mitochondrial efficiency and promotes a shift toward lipid utilization for energy, which can be especially beneficial in endurance and fat-loss settings (Price et al., Cell Metabolism )

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The ORR was 3.0% for emibetuzumab plus erlotinib and 4.3% for emibetuzumab alone among patients with available post-erlotinib progression biopsies