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342 They recapitulated a 12-residue stretch of this helix to contain a chelating hydroxamic acid warhead to target the HDAC active site Zn 2+ , and introduced a lactam staple between l-isoaspartic acid and 2,3-diaminopropionic acid as substitutes for the common Asp-Lys pair, a strategy they previously reported and validated in the context of ER α targeting
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