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Therefore, we suggest that the inflammatory pathway is an additional mechanism underlying ISO-induced cardiotoxicity ( RAGE signaling also can provoke an inflammatory reaction via amplifying various cellular cascades that enhance inflammatory cytokine release and promote activation of the NF-κB/p65 pathway, culminating in an enormous inflammatory reaction ( It has been documented that mitochondrial oxidative stress triggers numerous cell signaling pathways, including apoptosis ( On the other hand, Beclin1 is the critical gene that regulates cardiac autophagy and autophagosome formation ( AV is extensively used in folk remedies throughout the world due to its well-known anti-inflammatory and immunomodulatory effects ( Notably, ongoing research indicates that pre-treatment with AV could alleviate the cardiac damage triggered by ISO, as revealed by the considerable improvement in cardiac serum biomarkers in a dose-dependent manner

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