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First, to identify the clusters, the deconvolved (5 iterations) and bleached corrected images were filtered using a combination of Laplacian filter (3 pixels), to enhance their contrast, and the Gaussian filter (1 pixel), to reduce the background

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At nanomolar concentrations (1 to 10 nM), it stimulates collagen, glycosaminoglycan, and proteoglycan synthesis in dermal fibroblasts

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