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Long-term comparative data from Korea suggest dutasteride may outperform finasteride in sustained hair regrowth, and the topical route offers the same systemic-avoidance rationale as topical finasteride
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But, the growing number of patients with no or low response to PDE5I, and the potential of adverse reactions have prompted the development of safer and more effective treatments ( Figure 1 Drug therapy: Phosphodiesterase 5 inhibitors Phosphodiesterase 5 (PDE5) is highly expressed in vascular smooth muscle and it is the most common PDE subtype in penile smooth muscle
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