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6 Bevacizumab (Avastin ® ): 4,5 Approved as: first-line treatmentThe first treatment given for a disease of unresectableUnable to be removed by surgery, locally advancedHaving spread from where it started to nearby tissue or lymph nodes, recurrentHaving come back after a period of time during which the cancer could not be detected, or metastaticHaving spread from the primary site, or place where it started non–squamous NSCLC in combination with the chemotherapiesTreatment with drugs that kill cancer cells carboplatin (Paraplatin®) and paclitaxel (Taxol® or Onxol®) first-line treatment for adult patients with metastatic non-squamous NSCLC with no EGFR or ALK mutations, in combination with paclitaxel (Taxol® or Onxol®), carboplatin (Paraplatin®), and the immunotherapy drug atezolizumab (Tecentriq ®) Ramucirumab (Cyramza ® ) : 7 Approved: in combination with the chemotherapy docetaxel (Taxotere®) for the second- or subsequent-line treatmentTreatment that is usually started after the first set of treatments doesn’t work, has stopped working, or has side effects that are not tolerated of patients with metastaticHaving spread from the primary site, or place where it started non-small cell lung cancer whose disease has progressed while on or after taking platinum-based chemotherapy (for example, cisplatin (Platinol-AQ®) or carboplatin (Paraplatin®))