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The combination of the amylin analogue pramlintide and the recombinant human leptin metreleptin caused significant weight reductions ( - 11.5±kg) in comparison with monotherapy in a 24-week phase 2 clinical trial [248]
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Some women require titration to a strength between available options—particularly during the initiation phase or when fine-tuning a regimen for symptom control with minimal side effects
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