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Hypothalamic nuclei including ARC, PVN, dorsomedial, and ventromedial (VMH) nuclei contain high levels of key enzymes modulating lipid metabolism, such as AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC), carnitine palmitoyltransferase 1 (CPT1), fatty acid synthase (FAS), and malonyl-CoA decarboxylase [151]
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