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Thiamine hydrochloride (vitamin B1) in the formulation is known to cause life threatening anaphylaxis especially on multiple administrations if patient is allergic to it

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The bacterium secretes a variety of virulence factors, including cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA), which play a key role in causing gastric inflammation and epithelial cell damage (de Brito et al., 2019)