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Notably, biochemical and crystallographic assays suggest that roxadustat has affinity to thyroid hormone receptor β and affects the negative feedback loop in the hypothalamic-pituitary-thyroid axis (Yao et al., 2019)
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It has been reported that B vitamin group plays a vital role in maintaining immune homeostasis, cofactors and coenzymes in various metabolic pathways (Hosomi & Kunisawa, 2017
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