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These EAATs have the highest expression in oligodendrocytes during early development and may regulate oligodendrocyte maturation, extracellular glutamate homeostasis and CNS myelination [251, 252]

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A hallmark approach is to use synthetic modifications to stabilize local and global structural motifs, which can theoretically provide enhanced affinity and specificity for intended molecular targets, as well as vastly improved pharmacological properties (Figure 1B)