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Unlike the viral vector studies (Hovatta et al., 2005), this study demonstrated the physiological relevance of Glo1 in behavior, because Glo1 was expressed under its endogenous promoter elements, in its natural expression pattern, and throughout the animal's life

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Under physiological conditions, the intracellular GSH/GSSG ratio is higher than 100:1 to maintain intracellular redox homeostasis, but it decreases by 10 folds or less under oxidizing conditions