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Proteomic and functional analyses in this model suggested that prostaglandin reductase 1 expression was linked with the breast cancer sensitivity to AUF/AA combination ( The synergistic effect of ascorbate in the treatment of various types of cancer has been observed not only in combination with chemotherapeutic drugs but also in treatments with ionizing radiation ( In vitro , AA has been shown to potentiate the cytotoxic effect of ionizing radiation in various pancreatic cancer cell lines, but not in non-tumorigenic cell lines

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