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1 Introduction Nearly 213,795 research studies on asthma have been carried out in the last 50 years ( Systems biology elucidates the diverse types of high-dimensional interactions among molecular signaling networks, leading to cellular interactions that affect the biological processes associated with system physiology ( A systems biology methodology is developed in this study to conduct a systematic literature review of the current understanding of the airway and CNS microenvironments in asthma

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