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In cross-sectional studies, low circulating IGF-I levels were found to be associated with angiographically documented coronary artery disease [275] and may predict fatal ischemic heart disease [272], a significantly increased risk of ischemic stroke and congestive heart failure in elderly patients [276,277], as well as a worse prognosis of recovery after an acute myocardial infarction [278]

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(3) Thus, GHK-Cu is posited to act as a repair signal, capable of interacting with enzymes, ion channels, and cell-surface receptors, with reported downstream potential on gene expression