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MM-PBSA calculations reflected that all of the designed peptides showed significantly higher binding free energy toward CR3 than FOXO4-DRI (Fig
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Although low serum B12 levels have been associated with increased bone turnover and fracture risk (9) , long-term B12 and folic acid supplementation did not improve bone mineral density (38) , or reduce osteoporotic fracture incidence in elderly individuals with elevated plasma homocysteine levels (39)
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