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326 On the basis of the aforementioned research, increasing interest has been directed toward various NAD + precursors or small-molecule activators, which aim to increase the activity of sirtuins
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Disruption of mitochondria-ER interactions occurs in the early stage of hepatic insulin resistance, and targeting mitochondria-ER interactions has been proven to be effective in improving insulin resistance in diabetic mice ( in vitro and in vivo , with a disruption of mitochondria-ER interactions in hepatocytes or mice induced by HFD and high-sucrose diet counteracted by coadministration of SFN ( FIGURE 2 3.3 SFN and xenobiotic-induced liver injury Liver injury induced by xenobiotics, such as drugs, endocrine-disrupting chemicals, pollutants, and herbs, is an important part of liver diseases that could lead to liver failure or even death ( in vivo models (Figure 3)