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Identified through peptide phage display libraries, the LTV peptide exhibits high affinity and specificity for binding to PCa cells ( Moreover, in a study, an innovative strategy was employed to enhance the therapeutic index of interleukin-12 (IL-12) by targeting its delivery to tumors ( 2.4 Modulating cytokines in the tumor microenvironment using peptides Cytokines play pivotal roles in orchestrating immune responses and driving the progression of PCa (Wise et al., 2000)