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Abbreviations ANOVA: One-way analysis of variance AUC: Area under the concentration-time curve C max : Maximum serum drug concentration CYP: Cytochrome P450 enzymes DMSO: Dimethyl sulfoxide FPIA: Fluorescence polarization immunoassay H-D: High dose HPLC: High-performance liquid chromatography K e : Elimination rate constant L-D: Low dose M-D: Medium dose NADPH: Nicotinamide adenine dinucleotide phosphate N-C: Negative control NCD: Noncommunicable disease P-C: Positive control rpm: Revolutions per minute SD: Sprague–Dawley t 1/2 : Elimination half-life T max : Time to reach maximum serum drug concentration