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This requires considering both intrinsic factors (e.g., genetics, neuroplasticity, individual biology) and extrinsic factors (e.g., social and family environment, lifestyle, external conditions) [Reference Manchia, Pisanu, Squassina and Carpiniello13–Reference Lippard and Nemeroff17] as well as their interaction

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This suggests that accumulated BAs induce M2 TAM polarization by altering the metabolic pattern in macrophages, in addition to interacting with BA receptors