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90 The VGSC inhibitor phenytoin 91 inhibits breast cancer growth in preclinical models, and other inhibitors against these classes of sodium channels are under development for the treatment of cancer, including ropivacaine, 81,92,93 carbamazepine, 87,92,93 lamotrigine, 92,93 fosphenytoin, 92,93 and others (Table 1)

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The original approved version was discontinued in 2008 for commercial reasons, not safety concerns