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One of the major challenges encountered is the heterogeneity in study design, sample size, population characteristics, and dosage and duration of supplementation
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NEURON is good at modeling in detail the dynamics of individual neurons and synapses so that it can be used to investigate how ion channelopathies or modifications of synaptic receptors (e.g., NMDA/GABA imbalances) disrupt E/I ratios in mutations associated with autism [74],[75]
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