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The magnitude of these changes, −8.6mm Hg for SBP and −3.1 mm Hg for DBP, represents a clinically relevant reduction in a patient population which is considered difficult to treat

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For quantification of sulfur-containing metabolites in cultured cancer cells and mouse serum, 10 µl samples were extracted with 90 µl of ice-cold extraction solvent (80% methanol and 20% H 2 O) containing isotope-labelled internal standards (36 µM 13 C 2 15 N-GSH, 0.92 µM 13 C 4 15 N 2 -GSSG and 10 µM D 4 -cystine)