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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 2017, 37 (1), 71–84

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On one hand, it activates the Nrf2 pathway via VDR, inducing the expression of antioxidant enzymes such as superoxide dismutase (SOD), GPX, and CAT to increase ROS scavenging, while simultaneously downregulating iNOS and NADPH oxidase to limit ROS production (23, 28)

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