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12 REGULATION OF HEPATIC SAME CONTENT Due to the importance of SAMe as a regulator of multiple hepatic functions, the hepatic content of SAMe must be maintained constant independently of the daily intake of methionine, or of the ingest of betaine and choline, the only two dietary compounds that can supply the methyl group for methionine synthesis, or of the endogenous synthesis of 5-MTHF

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La gran mayoría de los datos proviene de estudios in vivo realizados en modelos murinos y de rata, así como de experimentos in vitro en cultivos celulares