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Subcutaneous injection Standard: 250 mcg once daily Higher protocol: 500 mcg once daily, or 250 mcg twice daily (morning and evening) Acute injury loading: 500 mcg twice daily for 2 weeks, then dropping to 250 mcg daily Injection site: subcutaneous abdominal fat, or near the injury if practical (the "local injection" approach some protocols favor) Duration: 4 to 8 weeks, then reassess Oral Standard: 250 to 500 mcg once or twice daily Used primarily for GI targets Typically dosed on an empty stomach, 20 minutes before food Cycling Common approach: 4 weeks on, 2 to 4 weeks off, re-evaluate Most prescribers don't recommend continuous use beyond 8 weeks without a check-in These are general clinical ranges
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731 These findings provide new and effective targets for the treatment of cerebral I/R injury
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