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A study from The Netherlands (Riphagen, 2020) found that after 8.5 years of follow-up of an older cohort (median baseline age=65), a doubling of baseline MMA levels was associated with an increased risk of mortality (HR 11.48, CI 3.32–39.64)

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The mRNA and protein expression of hypoxia-inducible factor 1α is upregulated in endothelial cells at high glucose levels in vitro