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Recent advancements in drug delivery systems, particularly nanotechnology, have further enhanced the feasibility of melatonin-based ocular treatments by improving its solubility, stability, and permeability across ocular barriers (77, 78)

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In patients with ovarian cancer, high-dose intravenous vitamin C (IVC) administered in combination with carboplatin and paclitaxel enhanced chemosensitivity and reduced adverse side effects of chemotherapy (Ma et al., 2014)