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Although methods exist for determining chromium in various biological media (urine, blood, exhaled air 46,108 ), the most common and accessible approaches measure total chromium, not reliably differentiating its valence states – toxic Cr(vi) and less toxic Cr(iii)

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This reduces the formation of proinflammatory cytokines, such as IL-9 and TNF-α and also has vasodilator properties by increasing cyclic GMP levels and by contributing to the regeneration of endothelial-derived relaxing factor