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Avoid hot water, exercise, or intense heat at that site for at least 4 hours, as these can increase blood flow and further disperse any medication that did enter

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Thus, when warfarin is loaded rapidly at greater than 5 mg per day, to co-administering heparin, an anticoagulant that acts upon antithrombin and helps reduce the risk of thrombosis, is beneficial, with warfarin therapy for four to five days, to have the benefit of anticoagulation from heparin until the full effect of warfarin has been achieved